Course List of Hokkaido Summer Institute
Leading and Advanced Materials Chemistry and Engineering II （Frontier of Bio-Electrochemistry）
This seminar covers the recent studies on active probes for multimodality molecular imaging in vivo. Precise measurement of enzyme activity in living systems with molecular imaging probes is becoming an important technique to unravel the functional roles of different enzymes in biological processes. Activatable probes whose imaging signal can be specifically switched from the “off” to “on” state upon interaction with a target of interest, are particularly attractive due to their improved sensitivity and specificity. The principle, history and recent development of this technique will be introdued. It will be focused on their applications for multimodality imaging （fluorescence, MRI and PET） of different biological events in living cells and animals.
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